Intermittent fasting (IF), or time-restricted feeding, is an emerg- ing dietary intervention that restricts intake of food and energy for a given period.

Not only does this method restrict total caloric in- take, it also promotes metabolic homeostasis by supporting circa- dian feeding rhythms.1,2

Only in the most recent 200 years have humans been able to access supplies of vast amounts of food and resources, which has caused a shift in disease patterns, particularly for metabolic syndromes and obesity.

The idea that reducing caloric intake can result in evolutionary cellular responses for survival has been an active research topic,3 but with the recent public awareness and interest in IF, many clinical studies have been published more recently. On December 2019, de Cabo and Mattson4 published a review article that discusses the mechanisms and current clinical evidence for IF. This review article discusses various broad-spectrum benefits of IF, with a positive outlook for more clinical evidence in the future.